Understanding Your Oncotype DX Test Results

Once you have been tested, your doctor will receive a report with the results of the Oncotype DX breast cancer test. The information in this report can help you and your doctor make a more confident decision about your treatment following surgery.

Your Oncotype DX test report includes a Recurrence Score result (for patients with early-stage invasive breast cancer) or a DCIS Score result (for patients with non-invasive breast cancer), which is a number between 0 and 100. The lower the Recurrence Score or DCIS Score, the lower the chances are that a woman's breast cancer will come back; the higher the Recurrence Score or DCIS Score, the greater the chances that the breast cancer will come back. In the case of early-stage invasive breast cancer, the Oncotype DX test is the only genomic test that can also predict whether a woman will benefit from chemotherapy. The lower the Recurrence Score result, the less likely a woman is to benefit from chemotherapy, and the higher the Recurrence Score result, the more likely she is to benefit from chemotherapy.

The following tables provide general guidelines for interpreting your score. Your doctor will help you understand the meaning of your results.

Oncotype DX Breast Recurrence Score Test (for early-stage invasive breast cancer)

Over 50 Years Old:

Recurrence Score Result

What the Score Means

0-25 The breast cancer has a low risk of recurrence with hormonal therapy. There will be no benefit from chemotherapy.
26-100 The breast cancer has a high risk of recurrence with hormonal therapy, and the benefit of chemotherapy are likely to be substantial.

50 Years Old or Younger:

Recurrence Score Result

What the Score Means

0-15 There will be no benefit from addition of chemotherapy to hormonal therapy.
16-20 There will be approximately 1.6% chemotherapy benefit in addition to hormonal therapy.
21-25 There will be approximately 6.5% chemotherapy benefit in addition to hormonal therapy.
26-100 The breast cancer has a high risk of recurrence with hormonal therapy alone, and there will be substantial benefit from chemotherapy.

Oncotype DX Breast DCIS Score Test (for stage 0, DCIS breast cancer)

DCIS Score Result

What the Score Means

Lower than 39 The breast cancer has a low risk of local recurrence. The benefit of radiation therapy is likely to be small and will not outweigh the risks of side effects.
Between 39 and 54 The breast cancer has an intermediate risk of recurrence. It is unclear whether the benefits of radiation therapy outweigh the risks of side effects.
Greater than 54 The breast cancer has a high risk of recurrence, and the benefits of radiation therapy are likely to be greater than the risks of side effects.

 

Your Oncotype DX test results also provide additional information, including the activity levels of the estrogen, progesterone and HER2 receptor genes in your tumor. You and your doctor will consider your score, along with these factors and others such as your age and the stage and grade of your tumor, to make a more informed, individualized treatment decision.